Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for ALLOPURINOL. Description and Brand Names. US Brand Name. Aloprim. Descriptions. Allopurinol injection is used to prevent or treat high uric acid levels in. Medscape - Indication-specific dosing for Zyloprim, Aloprim (allopurinol), IV: mg/m²/day; not to exceed mg/m²/day; may administer as single.
Allopurinol iv - remarkable
Robins , in a search for antineoplastic agents. Agonists: 8-Aminoadenine Adenine. Further azathioprine dosage reduction or use of an alternative therapy is recommended for patients who have low or absent thiopurine methyltransferase activity, as both the thiopurine methyltransferase and xanthine oxidase pathways are affected. Unlike uricosuric agents, which increase the urinary excretion of uric acid, allopurinol interferes with the catabolism of purines. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase , including Lesch—Nyhan syndrome ; glucose 6-phosphatase including glycogen storage disease ; phosphoribosyl pyrophosphate synthetase , phosphoribosyl pyrophosphate amidotransferase ; adenine phosphoribosyltransferase. Gout flares may occur after initiation of urate lowering therapy, such as allopurinol iv,
due to changing serum uric acid concentrations resulting in mobilization of urate from tissue deposits. Aluminum Hydroxide; Magnesium Alopurinol Minor Aluminum hydroxide decreases the oral bioavailability of allopurinol, possibly by inhibiting gastrointestinal click here
of allopurinol. The uric acid failure status in those patients is unknown. Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. For the prevention of acute hyperuricemia during chemotherapy or radiation treatment of leukemia, lymphoma, or solid tumors that may cause tumor lysis syndrome. The plasma half-life of allopurinol is 1—2 hours. View Metrics. Present in milk—not known to be harmful.