Drug Information on Lioresal (baclofen) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. 5–10 mg 3 times a day. 5 mg twice daily. Treatment with continuous pump- administered intrathecal baclofen should be initiated within 3 months of a. days and then wait more days before adding further 10 mg tablets, etc. These would be added sequentially to a three-times-per-day dosing of the baclofen. Skeletal muscle relaxants. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. How to take baclofen. Source your doctor you are breastfeeding before using baclofen. Take baclofen exactly as prescribed by your doctor. There is no brand-name version available. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Baclofen warnings. Subscribe to bacllofen newsletters.