Abstract—Oral and intrathecal baclofen (ITB) have been associated with epi- leptic seizures. The authors observed a higher incidence of epileptic seizures in. Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Abstract. Aims: Baclofen is a promising medication for the treatment of alcohol dependence, and the prescription of high-dose baclofen (HDB). It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Clinical status and EEG should be monitored at regular intervals during treatment. Monthly newsletter. Moderate Potential Hazard, Moderate plausibility. Consequently, the exact efficacy of low doses of baclofen on alcohol misuse is under debate, even if it bacofen that this molecule is quite safe at low doses Leggio et al. Email alerts New issue alert. The patient left the emergency department the next day, and before we were able to see him, he consumed alcohol again source subsequently experienced a new episode of seizures. FDA baclofen seizures for all medications. An continue reading and a computed tomography scan of the brain were performed, but neither found any anomaly.