Baclofen withdrawal can have unpleasant side effects and may also be painful. Learn how to identify withdrawal signs and stop using Baclofen. Withdrawal symptoms are more likely if baclofen is used for long periods of time ( more than a couple of months) and can. Baclofen can result in withdrawal symptoms that are severe. Baclofen withdrawal occurs when the brain becomes dependent upon the drug's effects, particularly. Drug Abuse Hotline. The management relies mainly on the reintroduction of baclofen. Therefore, seizures, autonomic instability and death may occur in ITB withdrawal syndrome even after controlling spasticity with dantrolene. Amiloride Benzamil Sffects. External link.