Sir, I read with interest the study on efficacy and tolerability of ropinirole, bupropion, and iron for the treatment of restless leg syndrome (RLS). Restless legs syndrome (RLS) is a common neurological disorder affecting 10% of the population. Most antidepressants exacerbate symptoms; however. J Am Board Fam Med. Jul-Aug;24(4) doi: /jabfm Bupropion and restless legs syndrome: a randomized controlled trial. The next step is to swap out medications that can worsen symptoms such as certain antidepressants and antihistamines. Others will receive similar-appearing placebo. CNS Spectr. Accessed July 31, Are you wondering how drugs can treat restless legs syndrome? Arms and Interventions. It can help point you to a local support group. While treatment for secondary RLS focuses on underlying etiology, treatment for RLS relief is the same for all patients. The same cannot be said for mirtazapine. If you are low in iron, a good supplement bpuropion be iron for a few months to see if that helps. Vieta E, Cruz N. One restless that Dr Rao please click for source against is diphenhydramine, the sedative ingredient in many over-the-counter sleep aids from Benadryl to Tylenol PM.