How Taking Wellbutrin Could Cause Weight Loss this guide will help give you basic information about bupropion and weight loss. The association is not a simple cause–effect relationship since many factors can contribute to weight gain, including depression itself.1 A systematic review . Our study reports an adverse weight gain on co-medication of escitalopram and on antidepressant use, weight gain as an adverse effect of antidepressants can be a .. Jaspers L. () Review: bupropion and SSRI-induced side effects. The only one not known to really affect weight much is Prozac it is more like a stimulant causes the least weight gain and Luvox and Paxil are the most sedating causing horrible horrible weight gain. Weight gain is a possible side effect of many antidepressant drugs. I am down bupeopion lbs in the first four weeks. Walgreen's also orders it if you request it. Honestly the XL has made my click ache, my cycle stop, my vision blurry, And my libido zilch. Kelle, did you have to weighf off of it gradually before going off? So I am so excited to start it again for weight loss. I was prescribed it and took it for nearly a year and gained 20 pounds in that timeframe. Every drug interacts with every person differently and it's rough trying different meds until you find the right one for you. Thanks a lot, doc. We comply with the HONcode standard for weiht health information - verify here. I see one person did well on another type it wasnt XL. Available for Android and iOS devices. I don't think it's the placebo effect, because I thought all brand and generics were the same. It has to be the Bupropion. Lupin Pharmaceuticals, Inc. I was trying to figure out why I felt differently and traced bupropon back to the pills. Hi, I too have gained 25 pounds over the years of taking Bupropion mgs per day! In the past week, I've gained 5 pounds! I had always heard wellbutrin doesn't cause weight gain. But that may have cajse due to having panic attacks, they truly make me lose my appetite. While you may feel better emotionally and mentally, dan might also feel discouraged by your physical appearance or health. I have gained about 8 pounds which is a lot for me because I am small. Weight came back anyway. The sensation of hunger disappears, so it is very easy to eat less and even skip meals. I am very tired and could sleep all day.