Baclofen oral liquid is indicated for the relief of spasticity of voluntary muscle resulting from such disorders as: multiple sclerosis, other spinal lesions, e.g. Find a comprehensive guide to possible side effects including common and rare side effects when taking Baclofen (Baclofen Tablets) for healthcare. Intrathecal baclofen may be used to treat spasticity in multiple sclerosis, it involves surgically implanting a pump under the skin of the abdomen. Learn more in. A: All patients and caregivers should receive information on the risks of the treatment. The risk or severity of adverse effects can be increased when Baclofen is combined with Loprazolam. The therapeutic efficacy read more Insulin Glulisine can be decreased when used in combination with Baclofen. Bradycardia ; hypothermia. Baclofen may decrease the excretion rate of Click subgallate which could result in a higher serum level. Brincidofovir may decrease the excretion rate of Baclofen which could result in a higher serum level. Individual interactants: Baclofen. The risk or severity of adverse effects can be increased when Baclofen is combined with Alimemazine.