Medscape - Depression, smoking cessation-specific dosing for Wellbutrin XL, Zyban (bupropion), frequency-based adverse effects, comprehensive interactions . Describes the medication bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL) an antidepressant drug used to manage depression, . Zyban (bupropion) is a prescription medication that can be used to stop smoking. Work out if it's the right medication for you. People with bulimia nervosa or a history of this. What is Zyban? Drug Class. You should start taking it a week or 2 before you try to quit. Common side effects affect between 1 in 10 and 1 in people Headache. Research has shown that all these methods can be effective. Related Drugs. Skip to Content. Difficulty passing urine or passing urine more frequently. People with high blood pressure hypertension. Can I take Zyban with other medicines? Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. Your questions answered:.